Your FREE western slope source for GOOD NEWS, entertainment & healthy living. Monthly, featuring good news, fun happenings & events, business promotion, vibrancy and positive energy.  Print edition available in 35+ communities on the western slope of Colorado.

Bacteria That Protects Against Food Allergies Identified; Represents a new paradigm for preventing sensitization to food - 2014 September  #5-8

Artist’s rendering of bacteria (stock illustration). Credit: © zuki70 / Fotolia

New study: Clostridia, a common class of gut bacteria, protects against food allergies
August 25, 2014, University of Chicago Medical Center: The presence of Clostridia, a common class of gut bacteria, protects against food allergies, a new study in mice finds. By inducing immune responses that prevent food allergens from entering the bloodstream, Clostridia minimize allergen exposure and prevent sensitization - a key step in the development of food allergies. The discovery points toward probiotic therapies for this so-far untreatable condition, report scientists from the University of Chicago, Aug 25 in the Proceedings of the National Academy of Sciences.
Although the causes of food allergy - a sometimes deadly immune response to certain foods - are unknown, studies have hinted that modern hygienic or dietary practices may play a role by disturbing the body’s natural bacterial composition. In recent years, food allergy rates among children have risen sharply, increasing approximately 50 percent between 1997 and 2011, and studies have shown a correlation to antibiotic and antimicrobial use.
“Environmental stimuli such as antibiotic overuse, high fat diets, caesarean birth, removal of common pathogens and even formula feeding have affected the microbiota with which we’ve co-evolved,” said study senior author Cathryn Nagler, PhD, Bunning Food Allergy Professor at the University of Chicago. “Our results suggest this could contribute to the increasing susceptibility to food allergies.”
To test how gut bacteria affect food allergies, Nagler and her team investigated the response to food allergens in mice. They exposed germ-free mice (born and raised in sterile conditions to have no resident microorganisms) and mice treated with antibiotics as newborns (which significantly reduces gut bacteria) to peanut allergens. Both groups of mice displayed a strong immunological response, producing significantly higher levels of antibodies against peanut allergens than mice with normal gut bacteria.
This sensitization to food allergens could be reversed, however, by reintroducing a mix of Clostridia bacteria back into the mice. Reintroduction of another major group of intestinal bacteria, Bacteroides, failed to alleviate sensitization, indicating that Clostridia have a unique, protective role against food allergens.
Closing the door
To identify this protective mechanism, Nagler and her team studied cellular and molecular immune responses to bacteria in the gut. Genetic analysis revealed that Clostridia caused innate immune cells to produce high levels of interleukin-22 (IL-22), a signaling molecule known to decrease the permeability of the intestinal lining.
Antibiotic-treated mice were either given IL-22 or were colonized with Clostridia. When exposed to peanut allergens, mice in both conditions showed reduced allergen levels in their blood, compared to controls. Allergen levels significantly increased, however, after the mice were given antibodies that neutralized IL-22, indicating that Clostridia-induced IL-22 prevents allergens from entering the bloodstream.

“This is absolutely testable as a therapeutic against a disease for which there’s nothing.” - Cathryn Nagler, PhD, Bunning Food Allergy Professor, University of Chicago


“We’ve identified a bacterial population that protects against food allergen sensitization,” Nagler said. “The first step in getting sensitized to a food allergen is for it to get into your blood and be presented to your immune system. The presence of these bacteria regulates that process.” She cautions, however, that these findings likely apply at a population level, and that the cause-and-effect relationship in individuals requires further study.
While complex and largely undetermined factors such as genetics greatly affect whether individuals develop food allergies and how they manifest, the identification of a bacteria-induced barrier-protective response represents a new paradigm for preventing sensitization to food. Clostridia bacteria are common in humans and represent a clear target for potential therapeutics that prevent or treat food allergies. Nagler and her team are working to develop and test compositions that could be used for probiotic therapy and have filed a provisional patent.
“It’s exciting because we know what the bacteria are; we have a way to intervene,” Nagler said. “There are of course no guarantees, but this is absolutely testable as a therapeutic against a disease for which there’s nothing. As a mom, I can imagine how frightening it must be to worry every time your child takes a bite of food.”
“Food allergies affect 15 million Americans, including one in 13 children, who live with this potentially life-threatening disease that currently has no cure,” said Mary Jane Marchisotto, senior vice president of research at Food Allergy Research & Education. “We have been pleased to support the research that has been conducted by Dr. Nagler and her colleagues at the University of Chicago.” (source: University of Chicago Medical Center. “Gut bacteria that protect against food allergies identified.” ScienceDaily, 25 August 2014. www.sciencedaily.com/releases/2014/08/140825152016.htm)

 

(See the front page in print...)

Submit a press release

 

Previous Editions of The Sunshine Express for sale: $3/each. Specify edition number or date when ordering. First edition #1-1 signed: $20/each. First year signed collector's set: $50/each. All orders include free shipping within the US. Include your name, delivery address, and email address or phone contact with your check or money order payable to:

The Sunshine Express, PO Box 267, Norwood, CO, 81423.

 

View every Sunshine Express edition online now in our always free Archives

Copyright 2010-2014 [TheSunshineExpress & westernslopenews.com]. All rights reserved. Revised 9/1/14.

Weather Forecast | Weather Maps

Website Calendar Software by KeepandShare

 

Breaking News:

 ~ Order your Ads in advance, space is limited.   Deadline for the October edition is midnight, Friday, September 26th.

We Accept: MasterCard, VISA, & Discover!

 

 

 

 

Advertise your business here with over 70 ads for only $1/day. Call to order: 970.864.2142 or 970.327.4196

 Check PageRank

Listen to our ad, airing on KKDC: 

   & KAYV:   & JACKfm:

Visit Our Website Sponsors By Clicking Their Ad

 

 

 

 

 

 

 

 

 

 

Visit Our Website Sponsors By Clicking Their Ad

Why advertise in The Sunshine Express?

It is visionary action by the people and small business owners that really creates life economically in America. Hopes, dreams, drive and effort can and do stimulate excitement, energy, business, and wallets on every corner, every day. Collectively across the country, these privately conceived 'stimulus plans' have historically been the true and consistent drivers of economic activity.
Recently, business magazine powerhouse Forbes agreed with us, writing, "Only productive private investment will spark economic revival."

Here are some of the many benefits of using The Sunshine Express as a foundational tool when creating your own 'private stimulus plan':

*** Consolidate marketing budgets and free up needed cash by targeting customers locally, plus in 35 more surrounding western Colorado towns, with one effective and affordable marketing tool that does both.

*** Achieve widespread and repetitive, multiple visual impressions ensuring positive, long term branding return on investment (translation: more people see and remember company names more often, guaranteed, bringing more customers over time)

*** Get free worldwide web and mobile exposure with clear mirror images of your ad online, plus archived, at westernslopenews.com

*** Receive personal service with extra promotional support including publication of business and related industry articles, reviews and news, social media promotions, low cost custom ad design service with free text changes, special event participation opportunities, & more.

*** Add value to your business name by association with a quality, positive, helpful and entertaining popular resource that uplifts, inspires and cares about the readership, the business clients and all of western Colorado.


Call or Email today to reserve your space: 970.864.2142 or 970.327.4196                 
Advertise now here...

 

The Sunshine  The Good News  The Reading Room  Health & Nurturing

Food & Garden   Nature   Happenings   Fun Stuff   Archives

Contact us     Submit Press Release     Sitemap     Privacy policy     Return to front page

Community Events Calendar

Sunshine Express Special Events

Advertising Info  and Ordering

Comments and Testimonials

Where To Pick Up Your Copy

About Us and Our Mission

Write To Us With Your Feedback

Free Newsletter Subscription

Photo Gallery

Buy Official Sunshine Express Merchandise & Souvenirs at:   Sunshine Express Gifts

 

Follow Us @SunshineXNews on: 

Like Us @SunshineXNews on:

Visit Us @SunshineXNews on:

 

  Bookmark and Share

The Sunshine   The Good News   The Reading Room   Health & Nurturing

Food & Garden   Nature   Happenings   Fun Stuff   Archives