randomization. Sixteen studies were double-blind
design; and one was a single-blind design.
...Probiotic species and dose used varied between
studies. Eight studies used a single species of
probiotics, whereas the others used a combina-
tion of equal or more than 2 species. All studies
reported good compliance with no side effects
from consuming probiotics, except for 2 studies
that reported subject flatulence, loose stools or
...All studies reported changes in fasting blood
glucose (FBG). Of the seventeen trials, four stud-
ies reported a significant reduction of FBG after
probiotic intervention, with mean differences
ranging from -0.15 to -1.51 mmol/L
...Overall, probiotics significantly reduced FBG
by 0.31 mmol/L, insulin by 1.17 ¦ÌU/mL and
improved HOMA-IR by 0.48, indicating a modest
effect of probiotics on glycemic control; however,
even small glucose reductions may provide health benefits. Abnormal glu-
cose metabolism carries crucial risks for many metabolic diseases, such as
obesity, diabetes, obstructive sleep apnea-hypopnea syndrome (OSAHS),
and cardiovascular disease.
...probiotics had a greater effect on FBG in people with diabetes and there
were only trends of glucose-lowing effect in those without diabetes, sup-
porting the notion that probiotics supplementation may generate a greater
benefit in individuals with higher FBG levels.
...Also, low-grade chronic inflammation is observed in diabetic and obese
individuals and the immune system is crucial for regulation of glucose
...Thus, our meta-analysis revealed a moderate beneficial effect of probiot-
ics on glycemic control along with lower insulin and HOMA-IR, data that are
consistent with a recent meta-analysis suggesting that yogurt intake was
associated with an 18% lower risk of T2DM. Modification of gut microbiota
by probiotic supplementation may be a method for preventing and control
hyperglycemia in clinical practice.
This study supported by the National Natural Science Foundation of China,
(81300689, 81403215). The funders had no role in study design, data col-
lection and analysis, decision to publish, or preparation of the manuscript.¡±
(sources: courtesy of Public Library of Science, www.ncbi.nlm.nih.gov/pmc/
articles/PMC4498615 and www.sepalika.com) [This content is not intended
to be a substitute for professional medical advice, diagnosis or treatment
and does not constitute medical or other professional advice.]
Systemic Review Reveals Diabetes/Probiotics Link
Probiotics decrease serum cholesterol levels, prevent insulin resistance
Ride the rockies
returns... Pg 4
What did you
say?... Pg 7
Blondie¡¯s gets even
An Evening with
Melissa... Pg 13
Probiotics play a huge role in digestion
and help boost immune response
Many of us are ignorant about the importance and
benefits of probiotics. Probiotics, or good gut bac-
teria, should ideally comprise at least 80% of the
total gut bacteria.
If you are diabetic, adding probiotics, as either
food or supplements, can change things dramati-
cally. Of course, you also need to eat the right
diet to feed the right bacteria after that. There is
strong scientific evidence supporting the fact that
consuming probiotics helps decrease the serum
cholesterol level and improves insulin sensitivity.
While probiotic supplements are highly recom-
mended for type 2 diabetes patients, some of the
best probiotics for diabetes also come from natu-
ral foods such as Kefir, Yogurt, Kimchi, Sauerkraut
According to research conducted at Loughborough
2017 JUN/JUL #8-3
University, probiotics prevent insulin resistance. Insulin resistance is often
caused by consuming foods that contain trans fats, for a long time. The
study found that a high trans-fat and processed food diet can reduce
insulin sensitivity by as much as 27%, in healthy adults. Supplementation
with probiotics helped normalize insulin functioning.
Below are highlighted excerpts from the study originally published July
¡°Probiotic consumption may improve glycemic control modestly. Modifica-
tion of gut microbiota by probiotic supplementation may be a method for
preventing and control hyperglycemia in clinical practice.
...Abnormal glucose metabolism is causally related to a greater risk of
several chronic disorders, including diabetes, obesity, dyslipidemia, and
cardiovascular diseases. Blood glucose can be controlled through diet
and lifestyle modification to prevent diabetes or related complications
and evidence suggests that dietary constituents and supplements such
as omega-3 fatty acids, dairy products, pistachio and coffee can improve
glycemic control or reduce an individual¡¯s risk of diabetes.
...Interestingly, research shows that gut microbiota are involved in diabe-
tes and metabolic disorders, revealing that diabetic patients have altered
gut microbiota compared to non-diabetic counterparts.
...Seventeen clinical trials involving 1,105 participants (551 probiotics,
554 control) were included and these trials were parallel RCTs that were
similar with regard to baseline characteristics, indicating successful
The term probiotic refers to dietary supplements and
foods that contain ¡°beneficial¡± or ¡°friendly¡± bacteria.
The organisms themselves are also called probiotics.