background image
Therefore, the objective of this
study was to discuss the research
trend of dementia treatment us-
ing cannabis, for the purpose of
providing the basis of cannabis use
for medical purposes in the future.
(source: www.journal-pharm.com/
sub/view/301)
2020 February/March
Pg 6 - The Sunshine Express
Health & Nurturing
medical purposes in the future.
Methods:
This study searched publications, which were
registered to databases or published by Aug 22,
2019, and targeted the full-text or abstracts of
these publications. We selected the final nine
studies that met all selection criteria.
Results:
These results implied that the CBD components
of cannabis might be useful to treat and prevent
Alzheimer¡¯s Disease(AD), because CBD compo-
nents could suppress the main causal factors of
AD.
Moreover, it was suggested that using CBD and
THC together could be more useful than using
CBD or THC alone.
Conclusion:
We hope that there will be a solid foundation to
use cannabis for medical use, by continuously
evaluating the possibility of using cannabis for
clinical purposes as a dementia treatment sub-
stance, and that cannabis can be used as a posi-
tive tool.
Discussion:
The interest in senile disease is rising gradually
because aging society has become a more
as medical cannabis, belongs to cannabinoids.
Cacao, the main ingredients of chocolate and
the caryophyllene of black pepper also belong
to cannabinoids. Cannabis contains at least 113
kinds of cannabinoids.
THC (¦¤-tetrahydrocannabidiol), CBD, CBG (Can-
nabigerol), and CBN (Cannabinol) are well-
known cannabinoids and many studies have
been conducted on them.
Using rats have shown that THC killed can-
cer cells and reduced tumor size. It has been
reported that CBG expands blood vessels and
protects the nervous system. Since CBN is effec-
tive for inflammation, pain control and insomnia,
patches containing CBN ingredients are commer-
cially available for human use.
Despite these advantageous effects, its use is
currently restricted in South Korea according
to the Narcotics Control Act (Law No. 15939)
in order to prevent health hazards due to drug
abuse. However, cannabis is legally used for
medical or recreational purposes in several
states of the US.
Although the medical efficacy and effects of
cannabis have been actively studied, cannabis
research is quite lacking in South Korea.
A Review on Studies of Cannabis for
Alzheimer¡¯s Disease; Focusing on CBD, THC
Kim Seok Hee 1, Yang Jin Won 2, Kim Kyung
Han 3, Kim Jong Uk 1, Yook Tae Han 1 *
1-Department of Acupuncture & Moxibustion
Medicine, Korean Medicine Hospital of Woosuk
University, Jeonju, Korea
2-Department of Pharmacology, College of Phar-
macy, Woosuk University, Wanju, Korea
3-Department of Preventive Medicine, College
of Korean Medicine, Woosuk University, Jeonju,
Korea
* Tae Han Yook. Department of Acupuncture &
Moxibustion Medicine, Korean Medicine Hospital
of Woosuk University, 46, Eoeun-ro, Wansan-gu,
Jeonju 54987, South Korea. Phone: +82-063-
220-8622 E-mail: nasiss@naver.com
[received date: 2019-11-19 / accepted date:
2019-12-12]
Abstract
Objectives:
This study was to discuss the research trend of
dementia treatment using cannabis, for the pur-
pose of providing the basis of cannabis use for
common phenomenon.
Types of dementia include AD, vascular
dementia, paralytic dementia, Lewy body
dementia, carbon monoxide induced
dementia and trauma dementia.
The onset of AD has continued to in-
crease since 1995, while the prevalence
of vascular dementia is gradually de-
creasing. Therefore, AD draws attention
from researchers.
AD is a disease that is caused by the
gradual degeneration and death of cere-
bral cortical cells.
The main symptoms are memory loss,
cognitive decline and behavioral dis-
orders. Histopathologically, overall
encephalatrophy, senile plaques, and
neurofibromatosis (NFT) are the common
characteristics of AD.
Acquired cognitive deficits caused by
AD have a significant impact on the
social life and activity of the patients.
Moreover, active treatment of memory
disorders greatly affects the prognosis of
AD patients.
Consequently, many researchers ac-
knowledge the need for a therapeutic
drug to restore the memory and cogni-
tive damages of AD patients, and various
studies have been conducted.
There are three Cannabis species: C.
sativa, C. indica and C. ruderalis. Canna-
bidiol (CBD), which is attracting attention
Alzheimer¡¯s & Cannabis Study
FASD & Cannabis
Study
¡°In children and young adults
with Fetal Alcohol Spectrum
Disorder, cannabis, mostly
cannabidiol (CBD), has been
associated with a marked and
statistically significant
improvement in serious
disruptive behavior.¡±
Use of Cannabis in Fetal Alco-
hol Spectrum Disorder
Gideon Koren, Rana Cohen and
Ornie Sachs.
Cannabis and Cannabinoid Re-
search. Ahead of print: doi.
org/10.1089/can.2019.0056
Online Ahead of Print:January 22,
2020
Abstract
Background:
Fetal alcohol spectrum disorder
(FASD) has been recently estimat-
ed to afflict up to 5% of American
children.
Most of these children exhibit